UCR

Cell Biology and Neuroscience



Scott N. Currie


Scott Currie
Phone: (951) 827-2411
Fax:
Office Location: 2380 Spieth Hall
Office Hours:
Email: currie@ucr.edu

Scott N. Currie, Ph.D.

Associate Professor
Ph.D. University of California, Davis

Biography

Homepage

The goal of my research is to understand the physiological mechanisms underlying the control of behavior. My main focus is the spinal cord and brainstem control of limb movements in the turtle (Trachemys scripta elegans). The nervous system must generate precise temporal sequences of muscle contraction when an organism produces a coordinated movement. These programmed sequences of muscle activity are referred to as "motor patterns", and are produced by rhythmically active networks of nerve cells called "central pattern generators" (CPGs) in the central nervous system. Most of my research has examined cellular and network-level mechanisms that are utilized by spinal cord CPGs in the turtle to generate coordinated scratching and swimming movements of the hindlimbs. More recently, I have begun investigating (1) pre-motor command systems in the turtle brainstem that activate locomotor CPGs in the spinal cord, and (2) the limb kinematics and EMG motor patterns that underlie lateral (yaw) turns during turtle swimming. See our turtle turning poster here, and a movie here.  I am also interested in the interactions and coordination between turtle locomotor and respiratory systems. The investigation of sensory-motor control mechanisms in biological neural networks has direct impact on the design of biomimetic control systems in robotics and new approaches to the treatment of human spinal cord injury and paralysis.

Ventral view of swimming turtle


Forward swim motor pattern recorded from 3 hindlimb muscle nerves: a knee extensor (red), an hip flexor (violet) and an hip extensor (blue).

Courses Taught

NRSC 200A. Fundamentals of Neuroscience: Molecular and cellular mechanisms. (Fall quarter)

NRSC 200C. Fundamentals of Neuroscience: Neural control of behavior. (Spring quarter)

NRSC 201. Graduate Neuroscience Laboratory:  Presents theoretical and practical aspects of modern methods and techniques used in nervous system research.  Faculty teach modules on methods in which they have special expertise.  Methods include, but are not limited to, light and fluorescence  microscopy, imaging ion concentrations within cells, immunocytochemistry, and electrophysiology of model systems.  (Fall quarter)

CBNS 106. Introduction to Neuroscience. (Winter quarter)

CBNS/PSYC 120. Cellular Neuroscience: Membrane & Synaptic Phenomena. Cellular and molecular mechanisms of nervous system function using concepts drawn from the study of vetebrates and invertebrates. (Summer Session)

CBNS/PSYC 120L. Undergraduate Neuroscience Laboratory: Laboratory experiments using anatomical, chemical, and physiological research methods fundamental to understanding neurons and neural systems. Students learn to (1) record bioelectric activity with extracellular and intracellular recording techniques, (2) acquire and analyze electrophysiological recordings with a computer, (3) monitor and quantify animal behavior and (4) interpret their data intelligently. (Winter quarter)

CBNS/PSYC 127. Behavioral Control Systems: Comparative analysis of the principles of nervous system initiation and control of behavior, concentrating on motor systems. Topics include: (1) command neurons and motor hierarchies, (2) simple reflexes, (3) CPGs and motor pattern generation, (4) neuromodulation of multifunctional networks, (5) simple vertebrate model systems for locomotion, (6) artificial neural networks, (7) development of behavior, (8) cortical control of voluntary movement, (9) motor learning and 'automaticity', and (10) neuroprosthetics (Spring quarter)

Publications

  • Welch, D.B. and Currie, S.N.  (2014)  Sensory-evoked turning locomotion in red-eared turtles: kinematic analysis and electromyography. J. Comp. Physiol. A. 200 (7): 641-656. DOI: 10.1007/s00359-014-0908-0.  
  • Currie, S.N.  (2012)  Bilateral hindlimb movement and motor patterns evoked by electrical microstimulation in the ventrolateral funiculus (VLF) of the turtle spinal cord.  Soc. for Neurosci. Abstracts, v. 38.   See Poster.
  • Currie, S.N.  (2011)  Donald M. Wilson (1932 - 1970): "The point that must be reached."  Neuroethology Newsletter (March issue): 9-14.   (See associated webpage here: donald-wilson.htm.)
  • Currie, S.N. (In preparation) Interaction between right and left hindlimb swim networks in the turtle spinal cord. To be submitted to the Journal of Neurophysiology.
  • Currie, S.N. (In preparation) Bilateral activity patterns in turtle abdominal muscles during breathing and swimming. To be submitted to the Journal of Experimental Biology.
  • Wang, S.C., Zhang, F., Zhu, H., Lu, C., Wang, Y-F. and Currie, S.N. (In preparation) Prostaglandins mediate suckling-induced milk ejections by activating burst discharges of rat supraoptic oxytocin neurons: Signaling. To be submitted to Science Signaling.
  • Samara, R.F. and Currie, S.N. (2008) Electrically evoked locomotor activity in the turtle spinal cord hemi-enlargement preparation. Neuroscience Letters 441: 105-109. pdficon
  • Samara, R.F. and Currie, S.N. (2008) Location of spinal cord pathways that control hindlimb movement amplitude and interlimb coordination during voluntary swimming in turtles. Journal of Neurophysiology 99: 1953-1968.   

  • Samara, R.F. and Currie, S.N. (2007) Crossed commissural pathways in the spinal hindlimb enlargement are not necessary for right-left hindlimb alternation during turtle swimming. Journal of Neurophysiology 98: 2223-2231.   

  • Wilbur, C., Vorus, W., Cao, Y. and Currie, S. (2002) A lamprey-based undulatory vehicle. In: Neurotechnology for Biomimetic Robots (J. Ayers, J. Davis, A. Rudolph, eds.). MIT Press, Cambridge, MA. Article PDF  [buy book]
  • Juranek, J. and Currie, S.N. (2000) Electrically evoked fictive swimming in the low-spinal immobilized turtle. Journal of Neurophysiology 83: 146-155.   

  • Currie, S.N. (1999) Fictive hindlimb motor patterns evoked by AMPA and NMDA in turtle spinal cord-hindlimb nerve preparations. Journal of Physiology (Paris) 93: 199-211.   

  • Currie, S.N. and Gonsalves, G.G. (1999) Reciprocal interactions in the turtle hindlimb enlargement contribute to scratch rhythmogenesis. Journal of Neurophysiology 81: 2977-2987.   

  • Currie, S.N. and Gonsalves, G.G. (1998) Crossed reciprocal inhibition and scratch rhythmogenesis in the turtle spinal cord. Ann. NY Acad. Sci. 860: 458-460.pdf icon

  • Stein, P.S.G., McCullough, M.L. and Currie, S.N. (1998) Spinal motor patterns in the turtle. Ann. NY Acad. Sci. 860: 142-154.   

  • Ayers, J., Zavracky, P., McGruer, N., Massa, D.P., Vorus, W.S., Mukherjee, R. and Currie, S.N. (1998) A modular behavioral-based architecture for biomimetic autonomous underwater robots. Proceedings of the Autonomous Vehicles in Mine Countermeasures Symposium. Naval Postgraduate School. (Published on CD). [html version]

  • Stein, P.S.G., McCullough, M.L., Currie, S.N. (1998) Reconstruction of flexor/extensor alternation during fictive rostral scratching by two-site stimulation in the spinal turtle with a transverse spinal hemisection. Journal of Neuroscience 18: 467-479.   

  • Currie, S.N. and Gonsalves, G.G. (1997) Right-left interactions between rostral scratch networks generate rhythmicity in the pre-enlargement spinal cord of the turtle. Journal of Neurophysiology 78: 3479-3483.   

  • Currie, S.N. and Lee, S. (1997) Glycinergic inhibition contributes to the generation rostral scratch motor patterns in the turtle spinal cord. Journal of Neuroscience 17: 3322-3333.   

  • Currie, S.N. and Lee, S. (1996) Sensory-evoked pocket scratch motor patterns in the in vitro turtle spinal cord: reduction of excitability by an N-methyl-D-aspartate antagonist. Journal of Neurophysiology 76: 81-92.   

  • Currie, S.N. and Lee, S. (1996) Glycinergic inhibition in the turtle spinal cord regulates the intensity and pattern of fictive flexion reflex motor output. Neuroscience Letters 205: 75-78.   

  • Stein, P.S.G., Victor, J.C., Field, E.C. and Currie, S.N. (1995) Bilateral control of hindlimb scratching in the spinal turtle: contralateral spinal circuitry contributes to the normal ipsilateral motor pattern of fictive rostral scratching. Journal of Neuroscience 15: 4343-4355.   
  • Currie, S.N., Wang, X.F. and Daw, N. (1994) NMDA receptors in layers II and III of rat cerebral cortex. Brain Research 662: 103-108.pdf icon
  • Currie, S.N. and Stein, P.S.G. (1992) Glutamate antagonists applied to midbody spinal cord segments reduce the excitability of the fictive rostral scratch reflex in the turtle. Brain Research 581: 91-100. pdf icon
  • Currie, S.N. (1991) Vibration-evoked startle behavior in larval lampreys. Brain Behavior & Evolution 37: 260-271.pdf icon
  • Currie, S.N. and Stein, P.S.G. (1990) Cutaneous stimulation evokes long-lasting excitation of spinal interneurons in the turtle. Journal of Neurophysiology 64: 1134-1148.    
  • Currie, S.N. and Stein, P.S.G. (1989) Interruptions of fictive scratch motor rhythms by activation of cutaneous flexion reflex afferents in the turtle. Journal of Neuroscience 9: 488-496.    
  • Currie, S.N. and Stein, P.S.G. (1988) Electrical activation of the pocket scratch central pattern generator in the turtle. Journal of Neurophysiology 60: 2122-2137.    

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Cell Biology and Neuroscience
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David Eastmond: Chair of Cell Biology & Neurosience
Tel: (951) 827-4497
Fax: (951) 827-3087
E-mail: david.eastmond@ucr.edu

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