UCR

Cell Biology and Neuroscience



David Eastmond


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Phone: (951) 827-4497
Fax: (951) 827-3087
Office Location: 2109 Biological Sciences
Office Hours:
Email: david.eastmond@ucr.edu

David A. Eastmond

Professor and Chair of the Department of Cell Biology & Neuroscience, and Research Toxicologist

Biography

Mechanisms of toxicity and carcinogenesis of agricultural and environmental chemicals in humans and other mammals.

Research in my laboratory focuses on the mechanisms involved in the toxicity and carcinogenesis of environmental and agricultural chemicals. One important goal of this research is to provide information allowing the potential adverse health effects associated with chemical exposure to be more accurately estimated. Our studies involve a variety of chemical, biochemical and molecular approaches using isolated enzymes, cells in culture and animal model systems. For a number of years we have studied the metabolism and chromosome-damaging effects of cancer-causing agents including benzene, a widely used industrial chemical and environmental pollutant, and ortho-phenylphenol, an extensively used fungicide and disinfectant.

In addition, we have an active research program which uses molecular cytogenetic techniques to detect chromosomal alterations occurring in chemically exposed human populations. These human biomonitoring approaches should allow the early detection of genotoxic effects and identify individuals at increased risk of developing cancer as well as allow early treatment or intervention strategies to be implemented. These studies generally involve applying fluorescence in situ hybridization with chromosome-specific DNA probes and related immunochemical techniques to detect chromosomal changes occurring in human cells isolated from the blood or other tissues from cigarette smokers or others with occupational exposure to benzene, pesticides, or other types of environmental exposures.

Notable Service and Recognitions

  • Member, Chemical Assessment Advisory Committee, U.S. EPA, Nov. 2013 to present.
  • Elected Fellow of the Collegium Ramazzini, Nov. 2011 to present.
  • Chair, Board of Scientific Counselors, National Toxicology Program, NIEHS, Feb. 2011 to Dec. 2012.
  • Member, Carcinogen Identification Committee, Science Advisory Board, Office of Environmental Health and Hazard Assessment, State of California, 1999 to 2003, 2005 to present.
  • Jefferson Science Fellow, US Department of State (administered by the National Academy of Sciences), Washington DC, 2004 to 2005.
  • President, Environmental Mutagen Society, May 2003 to Oct. 2004.

Publications

  • Zhang L, Steinmaus C, Eastmond DA, Xin XK, Smith MT (2009) Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms, Mutation Research – Reviews 681:150-168.
  • Guyton KZ, Kyle AD, Aubrecht J, Cogliano VJ.  Eastmond DA, Jackson M, Keshava N, Sandy MS, Sonawane B, Zhang L, Waters MD, Smith MT (2009) Improving Prediction of Chemical Carcinogenicity by Considering Multiple Mechanisms and Applying Toxicogenomic Approaches, Mutation Research – Reviews 681:230-240.
  • Eastmond DA, Hartwig, A, Anderson D, Anwar W, Cimino MC, Dobrev I, Douglas GR, Nohmi T, Phillips DH, Vickers C (2009) Mutagenicity testing for chemical risk assessment: Update of the WHO/IPCS harmonized scheme, Mutagenesis 24:341-349.
  • Eastmond, D.A. and Balakrishnan, S. (2010) Genotoxicity of Pesticides, in: Hayes’ Handbook of Pesticide Toxicology, 3rd Ed. (R. Krieger, ed.), Academic Press, San Diego, pp. 357-380.
  • Mondrala S. and Eastmond D.A. (2010) Topoisomerase II inhibition by the bioactivated benzene metabolite hydroquinone involves multiple mechanisms, Chemico-Biological Interactions 184:259-268.
  • Fenech M., Kirsch-Volders M., Natarajan A.T., Surralles J., Crott J.W., Parry J., Norppa H., Eastmond D.A., Tucker J.D., Thomas P. (2011) Molecular mechanisms of micronucleus, nucleoplasmic bridge, and nuclear bud formation in mammalian and human cells, Mutagenesis 26:125-132.
  • Roy SK, Eastmond DA (2011) Bimolane induces multiple types of chromosomal aberrations in human lymphocytes in vitro. Mutation Res. 726:181-187.
  • Eastmond DA (2012) Factors influencing mutagenic mode of action determinations of regulatory and advisory agencies. Mutation Res. Reviews 751:49-63.
  • Eastmond, DA (2012) Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment, Environmental Protection Agency, EPA/600/R-10/095F, 80 pp.
  • Vuong M, Hasegawa LH, Eastmond DA (2013) A comparative study of the cytotoxic and genotoxic effects of ICRF-154 and bimolane, two catalytic inhibitors of topoisomerase II. Mutation Res. – Genetic Toxicology and Environmental Mutagenesis 750:63-71. 
  • Spassova MA, Miller D, Eastmond DA, Nikolova, NS, Vulimiri SV, Caldwell J, Chen C, White PD (2013) Dose-response analysis of bromate-induced DNA damage and mutagenicity is consistent with low-dose linear, non-threshold processes, Environ. Molecular Mutagenesis. 54:19-35. 
  • Eastmond DA, Vulimiri SV, French JE, Sonawane B (2013) The use of genetically modified mice in cancer risk assessment: Challenges and limitations, Crit. Rev. Toxicology 43:611-631. 
  • Bhat VS, Hester SD, Nesnow S, Eastmond DA (2013) Concordance of transcriptional and apical benchmark dose levels for conazole-induced liver effects in mice, Toxicological Sci. 136:205-215. 

More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Department Information

Cell Biology and Neuroscience
2109 Biological Science

David Eastmond: Chair of Cell Biology & Neurosience
Tel: (951) 827-4497
Fax: (951) 827-3087
E-mail: david.eastmond@ucr.edu

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