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B. Glenn Stanley
Professor of Cell Biology & Neuroscience and Psychology
Graduate Advisor: Outreach and Recruitment
Email: glenn.stanley@ucr.edu
Our research aims are to identify the specific neurotransmitters and neurons involved in the control of eating
behavior, the regulation of body weight and the coordination of these behavioral processes with related autonomic
and endocrine systems. Additionally, we are attempting to understand the mechanisms and functional significance of
neurotransmitter interactions within these systems. Current projects involve investigating the mechanisms by which
four different neurochemical stimulants of eating behavior, neuropeptide Y, galanin, glutamate and norepinephrine,
act and interact with each other and with neurochemical appetite suppressants to control eating behavior. These
issues are investigated in freely-behaving rats using combinations of techniques involving central injections of
neurotransmitters and pharmacological agents with measures of elicited eating, induced changes in levels of
circulating hormones, or induced changes in brain metabolic activity. We also employ measures of neurotransmitter
release from specific brain areas in relation to spontaneously-occurring ingestive behavior.
Representative Publications:
- Duva, M.A., Tomkins, E.M., Moranda, L.M., Kaplan, R., Sukhaseum, A., Stanley, B.G. (2005) Origins of lateral
hypothalamic afferents associated with N-methyl-D-aspartic acid-elicited eating studied using reverse microdialysis
of NMDA and Flurogold. Neuroscience Research, 52(1), 95-106.
- Duva, M.A., Siu, A., and Stanley, B.G. (2005) Antagonist of NMDA receptors alters lipoprivic eating elicited
by 2-mercaptoacetate. Physiology and Behavior, 83, 787-791.
- Khan, A.M., Cheung, H.H., Gillard, E.R., Palarca, J.A., Welsbie, D.S., Gurd, J.W., and Stanley, B.G. (2004)
Lateral hypothalamic signaling mechanisms underlying feeding stimulation: Differential contributions of Src family
tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation. Journal of Neuroscience,
24(47), 10603-10615.
- Hettes, S.R., Gonzaga, J. Heyming, T.W., Perez, S., Wolfsohn, S. & Stanley, B.G. (2003) Dual roles in feeding
for AMPA/kainate receptors: receptor activation or inactivation within distinct hypothalamic regions elicits feeding
behavior, Brain Research, 992, 167-178.
- Blevins J.E., Stanley B.G. and Reidelberger, R.D. (2002) DMSO as a vehicle for central injections: Tests with
feeding elicited by norepinephrine injected into the paraventricular nucleus, Pharmacology Biochemistry and Behavior,
71(1-2), 277-282.
- Duva, M.A., Tomkins, E.M., Moranda, L.M., Kaplan, R., Sukhaseum, A., Bernardo, J.P. and Stanley, B.G. (2002)
Regional differences in feeding and other behaviors
elicited by N-methyl-D-aspartic acid in the rodent hypothalamus: a reverse microdialysis mapping study, Brain
Research, 925, 141-147.
- Duva, M.A., Tomkins, E.M., Moranda, L.M., Kaplan, R., Sukhaseum, A., Jimenez, A. and Stanley, B.G. (2001)
Reverse microdialysis of N-methyl-D-aspartic acid into
the lateral hypothalamus of rats: effects on feeding and other behaviors, Brain Research, 921, 122-132.
- Blevins, J.E., Stanley, B.G., & Reidelberger, R.D. (2000) Brain regions where cholecystokinin suppresses feeding
in rats, Brain Research, 860, 1-10.
- Blevins, J.E., Hamel, F.G., Fairbairn, E., Stanley, B.G., & Reidelberger, R.D. (2000) Effects of paraventricular
nucleus injection on CCK-8 on plasma CCK-8 levels in rats, Brain Research, 860, 11-20.
- Khan, A.M., Stanley, B.G., Bozzetti, L., Chin, C., Stivers, C. & Curras-Collazo, M.C. (2000) N-methyl-D-aspartate
receptor subunit NR2B is widely expressed throughout the rat diencephalon: An immunohistochemical study, Journal of
Comparative Neurology, 428, 428-449.
- Khan, A.M., Curras, M.C., Dao, J., Jamal, F., Turkowski, C.A., Goel, R.K., Gillard, E.R., Wolfsohn, S.D. &
Stanley, B.G. (1999) Lateral hypothalamic NMDA receptor
subunits NR2A and/or NR2B mediate eating: immunochemical/behavioral evidence. American Journal of Physiology,
276, R880-R891.
- Gillard, E.R., Khan, A.M., Mouradi, B., Nalamwar, O. & Stanley, B.G. (1998)
Eating induced by perifornical hypothalamic cAMP is
behaviorally selective and involves protein kinase activity. American Journal of Physiology, 275, R647-R653.
- Marin Bivens, C.L., Thomas, W.J. & Stanley, B.G. (1998). Similar feeding patterns are induce by perifornical
neuropeptide Y injection and food deprivation, Brain Research, 782, 271-280.
- Gillard, E.R., Khan, A.M., Grewal, R.S., Mouradi, B., Wolfsohn, S.D. & Stanley, B.G. (1998)
The second messenger cAMP elicits eating by an
anatomically specific action in the perifornical hypothalamus, Journal of Neuroscience,18, 2646-2652.
- Stanley, B.G., Butterfield, B.S., & Grewal, R.S. (1997). The NMDA receptor co-agonist glycine site: Evidence for
a role in lateral hypothalamic stimulation of feeding. American Journal of Physiology, 273, R790-R796.
- Gillard, E.R., Khan, A.M., Haq, A.U., Grewal, R.S., Mouradi, B., & Stanley, B.G. (1997). Stimulation of eating
by the second messenger cAMP in the perifornical and lateral hypothalamus. American Journal of Physiology, 273,
R107-R112.
- Aramakis, V.B., Stanley, B.G. & Ashe, J.H. (1996) Neuropeptide Y receptor agonists: Multiple effects on
spontaneous activity in the paraventricular hypothalamus. Peptides, 17, 1349-1357.
- Stanley, B.G., Willett III, V.L., Donias, H.W., Dee II, M.G. & Duva, M.A. (1996) Lateral hypothalamic NMDA
receptors and glutamate as physiological mediators of eating and weight control. American Journal of Physiology,
270, R443-R449.
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