None at this time

The Haga-Yamanaka Lab in the Department of Molecular, Cell, and Systems Biology at the University of California, Riverside is recruiting a postdoc. The position is immediately available. Our current research is focused on hormonal signaling in mammalian species. We employ multi-disciplinary approaches, including cell culture, reporter assays, histology, molecular biology, as well as in vivo physiological and behavioral studies, and mouse genetics, to understand molecular basis of hormone signaling and physiological consequences of the gain/loss of signaling in the brain and other tissues in vivo.

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Research Environment:

The Curras-Collazo Lab at the University of California Riverside is seeking a talented, highly motivated candidate to fill a Department of Defense-funded postdoc position. Our research team is uniquely positioned to combine research methods and manipulation techniques allowing an interdisciplinary approach to address important questions in gut-brain interactions and neurotoxicology.

The postdoc hire will serve a key role in research studies focused on the metabolic, inflammatory and cognitive/mood impairments associated with Gulf War illness (GWI) in a mouse model. We employ multi-disciplinary approaches, including behavior, physiology, molecular biology and toxicology to understand the etiology and pathophysiology of GWI. The postdoctoral researcher will be trained in desired research skill, will collaborate with other core members and have opportunities for teaching and mentoring.

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Several postdoctoral positions are available immediately for highly-motivated individuals interested in understanding the mechanisms underlying neural circuit function and development. The individuals will join one of multiple laboratories at the University of California, Riverside interested in 1) neuromodulation of perception and decision making, 2) brain circuit development, or 3) hormonal regulation of innate behavior.

Who you are:

·         A PhD or MD-PhD degree in neuroscience or related disciplines

·         Excellent communication skills

·         A demonstrated ability to work independently and learn new techniques

·         Candidates with less than 3 years of postdoctoral training are preferred

Who we are:

-     The Yang Lab: Our lab employs electrophysiology, calcium imaging, optogenetics and quantitative behavior approaches to understand the cellular and circuit mechanisms underlying neuromodulatory regulation of sensory processing and decision-making in mice. Solid experience in in vivo electrophysiology, or in vivocalcium imaging is required. Analytical skills with Matlab or Python is a plus. For more information, please visit https://www.hyanglab.com/positions. Send materials to: hongdian@ucr.edu. 

To Apply:  Interested applicants should submit a cover letter, CV and contact information for 3 references.  Positions are open until filled. 

The laboratory of Dr. Manuela Martins-Green in the Department of Molecular, Cell, and Systems Biology at the University of California, Riverside is looking for two highly motivated postdoctoral scholars to join its research team working on cell and molecular mechanisms of response to injury. 

Position one: The research will focus on determining whether injury caused by toxins, specifically third-hand smoke (THS) toxins, lead to epigenetic changes that result in reduced production of ATP. We also seek to determine whether those changes are passed on from generation to generation and for how long they might remain. This project will also involve other basic mechanisms of mitochondrial function affected by exposure to THS.  For these studies we have developed a novel exposure system of mice that mimics exposure of children to THS in homes of smokers.  The results we will obtain will have implications for policy changes to reduce/avoid exposure of children, elderly and those who live with smokers.

Position two: The research will focus with on basic cell and molecular mechanisms of initiation of chronic wound development.  We will be investigating how high levels of Oxidative Stress (OS) lead to changes in the genome, microbiome, proteome and metabolome that put the wound on a path to chronicity.  For these studies we have developed a novel chronic wound model in diabetic mice (db/db^-/-) which we have shown mimics chronic wounds in humans. When we raise the levels of OS right after wounding the wound goes on to become chronic with biofilm that contains biofilm-forming bacteria that are found in human chronic wounds.  We are now in a position to determine how high levels of OS put the wound on a path to chronicity.  The results we will obtain may lead to studies of proof-of-concept in humans with chronic wounds that could then lead to the development of new therapies for chronicity.

Qualifications for both positions: Applicants should hold a Ph.D. degree in Biological Sciences with an emphasis in cell and molecular biology and associated technology. Previous experience with metabolomics, proteomics, transcriptomics or bioinformatics would be helpful. Strong communication skills (both written and spoken) are required. Candidates should be able to work both independently and in a collaborative environment.

Salary:  Candidates will be offered a competitive salary commensurate with their experience

Individuals interested in applying should send their curriculum vitae (CV), a description of their research experience, a statement of research interests, and a list of three references via email to: manuela.martins@ucr.edu.

Dr. Weifeng Gu’s lab, located in the Department of Molecular, Cell and Systems Biology at UC Riverside, focuses on small noncoding RNA/RNAi-mediated gene regulation and antiviral response. We are looking for a highly motivated postdoc to examine how a highly conserved RNA phosphatase regulates genes and RNA viruses in C. elegans and other systems. This research involves RNA biogenesis, antivirus, gene regulation, innate immunity, developmental biology, genomics, RNAi, bioinformatics and cell biology.

The candidate is expected to have extensive knowledge and skills in RNA biology, biochemistry and genetics, with skills in bioinformatics and worm genetics as a plus. This position is funded by NIH and will support a postdoc for 4-5 years with a competitive salary and benefits.  UCR is a great place for working and living.

To Apply:  Please send a CV and a brief cover letter to Dr. Weifeng Gu at weifeng.gu@ucr.edu.

Two postdoctoral positions are available in the zur Nieden lab at the University of California Riverside to study how microRNAs tune early skeletal development. We have previously identified a powerful microRNA that enhances osteogenesis in vitro and now aim to analyze its role and that of its direct target in vivo using knockout and knock-in mice and genetic manipulation of Xenopus embryos. Similarly, we are interested in identifying how this and other microRNAs act to induce skeletal birth defects when embryos are exposed to environmental toxicants in utero.

The laboratory uses a combination of cellular (human ESCs, iPSCs, neural crest cells), molecular and genetic tools to understand how these microRNAs tune early differentiation - primarily that of the neural crest - to lay the foundation for proper craniofacial osteogenesis. For an overview of this and other projects in the lab please see our recent publications and the lab’s web page http://zurniedenlab.wix.com/ucrzurniedenlab.

Applications are invited from outstanding applicants with interests in neural crest, mesodermal or skeletal development and/or with an interest in stem cell biology and toxicology. Applicants are expected to work closely with collaborators Dr. Martin Garcia-Castro (University of California Riverside) and Dr. Bruce Blumberg (University of California Irvine) and in a team together with Graduate and undergraduate students.

Applicants should have a Ph.D and less than four years of postdoctoral experience. Knowledge in mouse breeding and husbandry, human embryonic stem cell culture and next generation sequencing is desirable. To apply send a curriculum vitae, bibliography and a cover letter with a brief description of research experience and the names of 3 references (with phone numbers) via e-mail to nicole.zurnieden@ucr.edu.

The Yang Lab at the University of California, Riverside is seeking talented, highly motivated candidates to fill 2 junior specialist positions. Our lab is uniquely positioned to combine state-of-the-art recording and manipulation techniques with computational modeling to address important questions in systems neuroscience.

Our current research is focused on the functions of subcortical neuromodulatory circuits. We employ multi-disciplinary approaches, including in vivo patch-clamp and multi-channel electrophysiology, calcium imaging, optogenetics, chemogenetics, quantitative animal behavior and computational modeling (e.g. Yang, Kwon, Severson, O’Connor, Nature Neuroscience 2016; Kwon, Yang, Minamisawa, O’Connor, Nature Neuroscience 2016; Yang, Shew, Roy, Plenz, Journal of Neuroscience 2012) to understand the cellular and circuit mechanisms underlying neuromodulatory regulation of sensory processing and decision-making in mice.

Position purpose

Under supervision, assist PI with research in the field of systems neuroscience.

Essential job functions

-Organize and keep laboratory mouse colony

-Assist with experiments for laboratory using a variety of behavioral, electrophysiological, and imaging approaches

-Prepare reagents, solutions and media

-Dissect mouse tissue and prepare it for histology

-Assist in data collection; keep records

-Assist in the assembly, testing and operation of complex laboratory equipment

Minimum requirements

-Bachelor’s degree

-Comfortable handling mice

-Experience of basic rodent behavior

-Knowledge of use of routine lab equipment

-College-level coursework including courses in the life sciences and/or demonstrated lab experience

Preferred qualifications

-Experience in histology

-Experience in electrophysiology or calcium imaging

-Bachelor’s degree in biology or related field

How to apply:

Interested applicants should submit a single PDF including a cover letter, CV and transcript to hongdian@ucr.edu. For additional information, please visit www.hyanglab.com.

The University of California is an Equal Opportunity/Affirmative Action Employer with a strong institutional commitment to the achievement of excellence and diversity among its faculty and staff. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other characteristic protected by law.

UCR is a world-class research university with an exceptionally diverse undergraduate student body. Its mission is explicitly linked to providing routes to educational success for underrepresented and first-generation college students. A commitment to this mission is a preferred qualification.