Molecular, Cell and Systems Biology

Michael E. Adams

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Phone: (951) 827-4746
Fax: Lab, not fax (951) 827-4369
Office Location: Office: 3107 Biological Sciences Building
Lab: 3206 Biological Sciences Building
Office Hours:
Email: michael.adams@ucr.edu

Michael E. Adams

Professor of Entomology and Neuroscience Ph.D. 1978, University of California, Riverside; DAAD Postdoctoral Fellow 1979; NATO Postdoctoral Fellow 1980

Research Area

Peptides and Behavior

Molecular and Cellular Physiology of Chemical Signaling

Our major research focus is on chemical signaling pathways that regulate developmental processes and behaviors. Discovery of the epitracheal endocrine system in insects and its secretory product, the ecdysis-triggering hormone (ETH), has revealed new insights into the endocrinology of ecdysis, the crucial stage through which insects must pass repeatedly during development from embryo to adult. ETH triggers a series of complex centrally patterned motor behaviors leading to ecdysis and thus provides an excellent model system for examining the relationships between gene expression, development, and animal behavior. More recent research is revealing functional roles for ETH in regulation of adult behaviors.


Deshpande, S., Meiselman, M., Hice, R., Arensburger, P., Rivera-Perez, C., Kim, D.-H., Croft, R., Noriega, F.G., and Adams, M.E. (2019) Ecdysis triggering hormone receptors regulate male courtship behavior via antennal lobe interneurons in Drosophila. Gen. Comp. Endocrinol. https://doi.org/10.1016/j.ygcen.2018.12.003.

Kaiser, M., Arvidson, R., Zarivach, R., Adams, M.E., and Libersat, F. (2019) Molecular cross-talk in a unique parasitoid manipulation strategy. Insect Biochem. Mol. Biol. https://doi.org/10.1016/j.ibmb.2018.11.009.

Arvidson, R., Kaiser, M., Lee, S.S., Urenda, J.-P., Dail, C., Mohammed, H., Nolan, C., Pan, S., Stajich, J., Libersat, F., and Adams, M.E. (2019) Parasitoid jewel wasp mounts multi-pronged neurochemical attack to hijack a host brain. Mol. Cell. Proteomics

Arvidson, R., Frankenberg, S., Landa, V., and Adams, M.E. (2018) Life history of the emerald jewel wasp, Ampulex compressa. J. Hymenoptera Res. 63: 1-13; doi: 10.3897/jhr.63.21762.

Moore, E.L., Arvidson, R., Banks, C., Urenda, J.P., Duong, E., Mohammed, H., and Adams, M.E. (2018) Ampulexins: A new family of peptides in venom of the emerald jewel wasp, Ampulex compressa. Biochemistry, DOI: 10.1021/acs.biochem.7b00916.

Kim, D.-H., Kim, Y.-J., and Adams, M.E. (2018) Endocrine regulation of airway clearance in Drosophila. Proc. Natl. Acad. Sci. doi:10.1073/pnas.1717257115/DCSupplemental.

Meiselman, M.R., Kingan, T.G., and Adams, M.E. (2018) Stress-induced reproductive arrest in Drosophila occurs through ETH-deficiency-mediated suppression of oogenesis and ovulation. BMC Biology, DOI 10.1186/s12915-018-0484-9.

Lee, S.S., Ding, Y., Karapetians, N., Rivera-Perez, C., Noriega, F.G., Adams, M.E. (2017) Hormonal signaling cascade during an early adult critical period required for courtship memory retention in Drosophila. Current Biology 27(18): 2798-2809.e3.

Meiselman, M., Lee, S.S., Tran, R.-T., Dai, H., Ding, Y., Rivera-Perez, C., Wijesekera, T.P., Dauwalder, B., Noriega, F.G., and Adams, M.E. (2017) Endocrine network essential for reproductive success in Drosophila melanogaster. Proc. Natl. Acad. Sci. doi: 10.1073/pnas.1620760114.

Tong, M.Q., Hasan, M. M., Lee, S. S., Haque, M. R., Kim, D.-H., Islam, M. D., Adams, M. E., Park, B. H. (2017) OCT intensity and phase fluctuations correlated with activity-dependent neuronal calcium dynamics in the Drosophila CNS. Biomed. Optics Express, 8(2): 726-735.

Kim, D.-H., Han, M.-R., Lee, G., Lee, S.-S., Kim, Y.-J., and Adams, M.E. (2015) Rescheduling behavioral subunits of a fixed action pattern by genetic manipulation of peptidergic signaling. PLOS Genetics 11(9): e1005513.

MacWilliam, D., Arensburger, P., Higa, J., Cui, X., and Adams, M.E. (2015) Behavioral and genomic characterization of molt-sleep in the tobacco hornworm, Manduca sexta. Insect Biochem. Mol. Biol. 62: 154-167.

Jiang, H., Wei, Z., Nachman, R.J., Adams, M.E., and Park, Y. (2014) Functional phylogenetics reveals contributions of pleiotropic peptide action to ligand-receptor coevolution. Scientific Reports 4: 6800.

Rozanski, G.M., Nath, A.R., Adams, M.E., and Stanley, E.F. (2013) Low voltage-activated calcium channels gate transmitter release at the dorsal root ganglion sandwich synapse. J. Physiol. 591(22): 5575-5583.

Cho, K.-H., Daubnerova, I., Park, Y., Zitnan, D., and Adams, M.E. (2013) Secretory competence in a gateway endocrine cell conferred by the nuclear receptor betaFTZ-F1 enables stage-specific ecdysone responses throughout development in Drosophila. Dev. Biol. 385: 253-262.

Zitnan, D. and Adams, M.E. (2012) Neuroendocrine Regulation of Insect Ecdysis. In: Insect Endocrinology, (L.I. Gilbert, Ed.), Elsevier Press, London, pp. 253-309.

Banks, C.N. and Adams, M.E. (2012) Biogenic amines in the nervous system of the cockroach, Periplaneta americana following envenomation by the jewel wasp, Ampulex compressa. Toxicon 59(2): 320-328.

Roller, L., Zitnanova, I., Dai, L., Simo, L., Park, Y., Satake, H., Tanaka, Y., Adams, M.E., and Zitnan, D. (2010) Ecdysis triggering hormone signaling in arthropods. Peptides 31: 429-441.

Chang, J.C., Yang, R.-B., Adams, M.E., and Lu, K.-Lu (2009) Receptor guanylyl cyclases in Inka cells targeted by eclosion hormone. Proc. Natl. Acad. Sci. USA 106(32): 13371-6.

Dai, L. and Adams, M.E. (2009) Ecdysis triggering hormone signaling in the yellow fever mosquito, Aedes aegypti. Gen. Comp. Endocrinol. 162(1): 43-51.

Kim, Y.-J., Nachman, R.J., Aimanova, K., Gill, S., and Adams, M.E. (2008) The pheromone biosynthesis activating neuropeptide (PBAN) receptor of Heliothis virescens: Identification, functional expression, and structure-activity relationships of ligand analogs. Peptides 29: 268-275.

Dai, L., Dewey, E.M., Zitnan, D., Luo, C.W., Honegger, H.W., and Adams, M.E. (2008) Identification, developmental expression, and functions of bursicon in the tobacco hawkmoth, Manduca sexta. J. Comp. Neurol. 506: 759-74.

Zitnan, D., Kim, Y.J., Zitnanova, I., Roller, L., and Adams, M.E. (2007) Complex steroid-peptide receptor cascade controls insect ecdysis. Gen. Comp. Endocrinol. 153: 88-96.

Dai, L., Zitnan, D., and Adams, M.E. (2007) Strategic expression of ion transport peptide gene products in central and peripheral neurons of insects. J. Comp. Neurol. 500: 353-67.

Kim, Y.-J., Zitnan, D., Galizia, C.G., Cho, K.-H., and Adams, M. E. (2006) A command chemical triggers an innate behavior by sequential activation of multiple peptidergic ensembles. Current Biol. 16: 1395-1407.

Kim, Y.-J., Zitnan, D., Cho, K.-H., Schooley, D.A., Mizoguchi, A., and Adams, M.E. (2006) Central peptidergic ensembles associated with organization of an innate behavior. Proc. Natl. Acad. Sci. USA 103: 14211-6.

Moore, E.L., Haspel, G. Libersat, F. and Adams, M.E. (2006) Parasitoid Wasp Sting: A Cocktail of GABA, Taurine and beta-alanine opens chloride channels for central synaptic block and transient paralysis of a cockroach host. J. Neurobiol. 66: 811-820.

Park, Y. and Adams, M.E. (2005) Insect G Protein-coupled receptors: Recent discoveries and Implications. In: Comprehensive Insect Biochemistry, Physiology, Pharmacology and Molecular Biology, (L. I. Gilbert, K. Iatrou, and S.S. Gill, Eds.), Elsevier Press, London, Vol. 5, pp. 143-171.

Zitnan, D. and Adams, M.E. (2005) Neuroendocrine Regulation of Insect Ecdysis. In: Comprehensive Insect Biochemistry, Physiology, Pharmacology, and Molecular Biology, (L.I. Gilbert, K. Iatrou and S.S. Gill, Eds.), Elsevier Press, London, Vol. 3, pp. 1-60.

Adams, M.E. (2004) Agatoxins. Toxicon 43: 509-525.

Kim, Y., Spalovska-Valachova, I., Cho, K., Zitnanova, I., Park, Y., Adams, M.E. and Zitnan, D. (2004) Corazonin Receptor Signaling in Ecdysis Initiation. Proc. Natl. Acad. Sci. USA 101: 6704-6709.

Park, Y., Y. J. Kim, V. Dupriez, and M.E. Adams. (2003) Two Subtypes of Ecdysis-triggering Hormone Receptor in Drosophila melanogaster. J. Biol. Chem. 278: 17710-5.

Zitnan, D., I. Zitnanova, I. Spalovska, P. Takac, Y. Park and M.E. Adams. (2003) Conservation of ecdysis-triggering hormone signalling in insects. J. Exp. Biol. 206: 1275-89.

Zitnan, D., L. Hollar, I. Spalovska, P. Takac, I. Zitnanova, S.S. Gill and M.E. Adams. (2002) Molecular cloning and function of ecdysis-triggering hormones in the silkworm Bombyx mori. J. Exp. Biol. 205: 3459-3473.

Park, Y., Y.J. Kim and M.E. Adams. (2002) Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc. Natl. Acad. Sci. U S A 12: 12.

Park, Y., V. Filippov, S.S. Gill and M.E. Adams. (2002) Deletion of the ecdysis-triggering hormone gene leads to lethal ecdysis deficiency. Development 129: 493-503.

Zitnanova, I., M.E. Adams, and D. Zitnan. (2001) Dual ecdysteroid action on epitracheal glands and the central nervous system preceding ecdysis of Manduca sexta. J. Exp. Biol. 204: 3483-3495.

Kingan, T. G., R. A. Cardullo, and M. E. Adams. (2001) Signal transduction in eclosion hormone-induced secretion of ecdysis-triggering hormone. J. Biol. Chem. 276: 25135-24142.

Zhao, Y., Y. Park, and M. E. Adams. (2000) Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segments of a voltage-gated sodium channel. Biochem. Biophys. Res. Comm. 278: 516-521.

Zitnan, D. and M. E. Adams. (2000) Excitatory and inhibitory roles of central ganglia in initiation of the ecdysis behavioral sequence. J. Exp. Biol. 203: 1329-1340.

Lee, D., M. Gurevitz and M. E. Adams. (2000) Modification of synaptic transmission and sodium channel inactivation by the insect-selective scorpion toxin LqhalphaIT. J. Neurophysiol. 83(3): 1181-7.

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Molecular, Cell and Systems Biology
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Manuela Martins-Green: Chair of Molecular, Cell and Systems Biology
Tel: (951) 827-2831
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E-mail: manuela.martins@ucr.edu