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Molecular, Cell and Systems Biology



Glenn I. Hatton (deceased)


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Email: glenn.hatton@ucr.edu

Glenn I. Hatton (deceased)

Professor

Biography

Our research uses a model systems approach to investigate basic principles underlying mammalian central nervous system structure-function relationships. Several phenomena are currently under study. [1] Ionic and molecular mechanisms involved in the excitability and bursting activity of neuroendocrine cells, with special attention to the bursting of oxytocin neurons that are involved in the milk ejection reflex. [2] Dynamic interactions between neurons and glia, particularly astroglia. [3] Modulation of neuronal activity patterns by calcium binding proteins, G-proteins, cyclic nucleotides and protein kinases.

Publications

  • Wang, Y-F. & Hatton, G.I. 2007. Interaction of extracellular regulated protein kinase 1/2 with actin cytoskeleton in supraoptic neurons and astrocytes: role in burst firing. Journal of Neuroscience, 27: 13822-13834.
  • Wang, Y-F. & Hatton, G.I. 2007. Dominant role of betagamma subunits of G-proteins in oxytocin-evoked burst firing. Journal of Neuroscience, 27: 1902-1912.
  • Wang, Y-F. & Hatton, G.I. 2006. Mechanisms underlying oxytocin-induced excitation of supraoptic neurons: prostaglandin mediation of actin polymerization. Journal of Neurophysiology, 95: 3933-3947.
  • Wang, Y-F., Ponzio, T.A. & Hatton, G.I. 2006. Autofeedback effects of progressively rising oxytocin concentrations on supraoptic oxytocin neuronal activity in slices from lactating rats. American Journal of Physiology, 291: R1191-1198.
  • Armstrong, W. E. & Hatton, G.I. 2006. The puzzle of pulsatile oxytocin secretion during lactation: some new pieces. Invited "In Focus" review. American Journal of Physiology, 291: R26-28.
  • Mercier, F., Mambie, S & Hatton, G.I. 2006. Brain macrophages: enigmas and conundrums. Chapter 6 in: Dermietzel, R., Spray, D.C. & Nedergaard, M. (eds.) Blood-brain interfaces: from ontogeny to artificial barriers. Wiley-VCH, Weinheim, Germany, pp. 129-165.
  • Ponzio, T.A., Ni, Y., Montana, V., Parpura, V. & Hatton, G.I. 2006. Vesicular glutamate transporter expression in supraoptic neurons suggests a glutamatergic phenotype. Journal of Neuroendocrinology, 18: 253-265.
  • Ponzio, T.A. & Hatton, G.I. 2005. Adenosine postsynaptically modulates supraoptic neuronal excitability. Jouranl of Neurophysiology, 93: 535-547.
  • Wang, Y-F & Hatton, G.I. 2005. Burst firing of oxytocin neurons in male rat hypothalamus slices. Brain Research, 1032: 36-43.
  • Hatton, G.I. 2004, Dynamic neuronal-glial interactions: an overview 20 years later. Peptides, 25:403-411.
  • Hatton, G.I. & Parpura, V. (Eds.) 2004, Glial-Neuronal Signaling, Kluwer, Amsterdam, 441 pp.
  • Hatton, G.I. 2004. Morphological plasticity of astroglial/neuronal interactions: functional implications. In: Hatton, G.I. & Parpura, V. (Eds.) Glial-Neuronal Signaling, Kluwer, Amsterdam, pp. 99-124.
  • Wang, Y-F & Hatton, G.I. 2004. Milk ejection burst-like electrical activity evoked in supraoptic oxytocin neurons in slices from lactating rats. Journal of Neurophysiology, 91:2312-2321.
  • Mercier, F. & Hatton, G.I. 2004. Meninges and perivasculature as mediators of CNS plasticity. In: Hertz, L. Non-Neuronal Cells of the Nervous System: Function and Dysfunction, Vol. 1, Elsevier, Amsterdam, pp. 215-253.
  • Song, Z. & Hatton, G.I. 2003, Taurine and the control of basal hormone release from rat neurohypophysis. Experimental Neurology, 183:330-337.
  • Mercier, F., Kitasako, J.T. & Hatton, G.I. 2003. Fractones and other basal laminae in the hypothalamus. Journal of Comparative Neurology, 455:324-340.
  • Hatton, G.I. & Yang, Q.Z. 2002. Synaptic potentials mediated by alpha7 nicotinic acetylcholine receptors in supraoptic nucleus. Journal of Neuroscience, 22: 29-37.
  • Hatton, G.I. & Yang, Q.Z. 2002. Peripartum interneuronal coupling in the supraoptic nucleus. Brain Research, 932:120-123.
  • Miyata, S. & Hatton, G.I. 2002. Activity-related, dynamic neuron-glial interactions in the hypothalamo-neurohypophysial system. Microscopy Research and Technique, 56: 143-157.
  • Mercier, F., Kitasako, J.T. & Hatton, G.I. 2002. Anatomy of the brain neurogenic zones revisited: fractones and the fibroblast/macrophage network. Journal of Comparative Neurology, 451:170-188.
  • Yang, Q.Z. & Hatton, G.I. 2002. Histamine H1-receptor modulation of interneuronal coupling among vasopressinergic neurons depends on nitric oxide synthase activation. Brain Research, 955:115-122.
  • Hatton, G.I. 2002. Glial/neuronal interactions in the mammalian brain. Advances in Physiology Education, 26:225-237.
  • Hatton, G.I. & Yang, Q.Z. 2001. Ionotropic histamine receptors and H2-receptors modulate supraoptic oxytocin neuronal excitability and dye coupling. Journal of Neuroscience, 21: 2974-2982.
  • Miyata, S., Takamatsu, H., Maekawa, S., Watanabe, K., Kiyohara, T. & Hatton, G.I. 2001. Plasticity of neurohypophysial terminals with increased hormonal release during dehydration: ultrastructural and biochemical analyses. Journal of Comparative Neurology, 434: 413-427.
  • Mercier, F. & Hatton, G.I. 2001. Connexin 26 and bFGF are primarily expressed in the subpial and subependymal layers in adult brain parenchyma: roles in stem cell proliferation and morphological plasticity? Journal of Comparative Neurology, 431: 88-104.
  • Mercier, F. & Hatton, G.I. 2000. Immunocytochemical basis for meningeo-glial networks. Journal of Comparative Neurology, 420: 445-465.
  • Miyata, S., Nakai, S., Kiyohara, T. & Hatton, G.I. 2000. Calbindin-D28k and calretinin in the rat posterior pituitary: light and electron microscopic localization and up regulation with dehydration. Journal of Neurocytology, 29: 5-17.
  • Li, Z. & Hatton, G.I. 2000. Histamine suppresses non-NMDA excitatory synaptic currents in rat supraoptic nucleus neurons. Journal of Neurophysiology, 83: 2616-2625.
  • Hatton GI. 1999. Astroglial modulation of neurotransmitter/peptide release from the neurohypophysis: present status. Journal of Chemical Neuroanatomy, 16: 203-222.
  • Li, Z., Miyata, S. & Hatton, G.I. 1999. Inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in rat supraoptic neurons: involvement in histamine-induced enhancement of depolarizing afterpotentials. Neuroscience, 93: 667-674.
  • Yang, Q.Z. & Hatton, G.I. 1999. Nitric oxide via cGMP-dependent mechanisms increases dye coupling and excitability of rat supraoptic nucleus neurons. Journal of Neuroscience, 19: 4270-4279.
  • Hatton, G.I. 1998. Synaptic modulation of neuronal coupling. Cell Biology International, 22: 765-780.
  • Hatton, G.I. & Li, Z. 1998. Intrinsic controls of intracellular calcium and intercellular communication in the regulation of neuroendocrine cell activity. Cellular and Molecular Neurobiology, 18: 13-28.
  • Hatton, G.I. & Li, Z-H. 1998. Mechanisms of neuroendocrine cell excitability. In: Zingg, H.H. & Bichet, D.G. (eds.) Vasopressin and Oxytocin: molecular, cellular and clinical advances. Plenum, New York, pp. 79-95.
  • Hatton, G.I. & Li, Z-H. 1998. Neurophysiology of magnocellular neuroendocrine cells: recent advances. Progress in Brain Research, 119: 77-99.
  • Miyata, S., Khan, A.M. & Hatton, G.I. 1998. Colocalization of calretinin and calbindin-D28k with oxytocin and vasopressin in rat supraoptic nucleus neurons: a quantitative study. Brain Research, 785: 178-182.
  • Yang, Q.Z. & Hatton, G.I. 1997. Electrophysiology of excitatory and inhibitory afferents to rat histaminergic tuberomammillary nucleus neurons from hypothalamic and forebrain sites. Brain Research, 773: 162-172.
  • Hatton, G.I. 1997. Function-related plasticity in the hypothalamus. Annual Review of Neuroscience, 20: 375-397.
  • Li, Z.-H. & Hatton, G.I. 1997. Reduced outward K+ conductances generate depolarizing afterpotentials in rat supraoptic nucleus neurons. Journal of Physiology, 505: 95-106.
  • Li, Z., & Hatton G.I. 1997. Ca2+ release from internal stores: Role in generating depolarizing afterpotentials in supraoptic nucleus neurones. Journal of Physiology, 498: 339-350.
  • Miyata, S., Matshushima, O. & Hatton, G.I. 1997. Taurine in rat posterior pituitary: localization in astrocytes and selective release by hypoosmotic stimulation. Journal of Comparative Neurology, 381: 513-523.
  • Micevych, P.E. Popper, P. & Hatton, G.I. 1996. Connexin-32 mRNA expression in rat supraoptic nucleus: up-regulation prior to parturition and during lactation. Neuroendocrinology, 63: 39-45.
  • Hatton, G.I. & Yang, Q.Z. 1996. Synaptically released histamine increases dye coupling among vasopressinergic neurons of the supraoptic nucleus: mediation by H1-receptors and cyclic nucleotides. Journal of Neuroscience, 1996, 16: 123-129.
  • Li, Z., & Hatton, G.I. 1996. Histamine-induced prolonged depolarization in supraoptic neurons: G-protein mediated, Ca2+-independent suppression of K+ leakage conductance. Neuroscience, 70: 145-158.
  • Li, Z., & Hatton G.I. 1996. Oscillatory bursting of phasically firing supraoptic neurones in low Ca2+ medium: Na+ influx, cytosolic Ca2+ and gap junctions. Journal of Physiology, 496: 379-394.
  • Li, Z., Decavel, C. & Hatton, G.I. 1995. Calbindin-D28k: Role in determining intrinsically generated firing patterns in rat supraoptic neurones. Journal of Physiology, 488: 601-608.

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