Molecular, Cell and Systems Biology

B. Glenn Stanley

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Phone: (951) 827-5625
Fax: (951) 827-2214
Office Location: 2111B Psychology
Office Hours:
Email: glenn.stanley@ucr.edu

B. Glenn Stanley

Professor of Psychology and of Molecular, Cell & Systems Biology


Our research aims are to identify the specific neurotransmitters and neurons involved in the control of eating behavior, the regulation of body weight and the coordination of these behavioral processes with related autonomic and endocrine systems. Additionally, we are attempting to understand the mechanisms and functional significance of neurotransmitter interactions within these systems. Current projects involve investigating the mechanisms by which four different neurochemical stimulants of eating behavior, neuropeptide Y, galanin, glutamate and norepinephrine, act and interact with each other and with neurochemical appetite suppressants to control eating behavior. These issues are investigated in freely-behaving rats using combinations of techniques involving central injections of neurotransmitters and pharmacological agents with measures of elicited eating, induced changes in levels of circulating hormones, or induced changes in brain metabolic activity. We also employ measures of neurotransmitter release from specific brain areas in relation to spontaneously-occurring ingestive behavior.


  • David, C.N., Frias, E.S., Szu, J.I., Viera, P.A., Hubbard, J.A., Lovelace, J., Michael, M., Worth, D., McGovern, K.E., Ethell, I.M., Stanley, B.G., Korzus, E., Fiacco, T.A., Binder, D. K., Wilson, E.H., (2016). GLT-1-dependent disruption of CNS glutamate homeostasis and neuronal function by the protozoan parasite Toxoplasma gondii.", PLOS: Pathogens. 12(6) (doi:10.1371/journal.ppat.1005643) 29 pages.
  • Urstadt, K.R. and Stanley, B.G. (2015) Direct hypothalamic and indirect trans-pallidal, trans-thalamic, or trans-septal control of accumbens signaling and their roles in food intake. Frontiers in Systems Neuroscience, 9, 1-18.(doi: 10.3389/fnsys.2015.00008).
  • Charles, J.R., Hernandez, E., Winter, A., Yang, C.R. and Stanley, B.G. (2015). Site selective activation of lateral hypothalamic mGluR1 and R5 receptors elicits feeding in rats. Physiology and Behavior. 139, 261-266.
  • Charles, J.R., Duva, M.A., Ramirez, G.L., Lara, R.L., Yang, C.R. and Stanley, B.G. (2014). Activation of lateral hypothalamic mGlu1 and mGlu5 receptors elicits feeding in rats. Neuropharmacology,79, 59-65.
  • Urstadt, K.R., Coop, S.H., Banuelos, B.D. and Stanley, B.G. (2013) Behaviorally specific versus non-specific suppression of accumbens shell-mediated feeding by ipsilateral versus bilateral inhibition of the lateral hypothalamus. Behavioral Brain Research, 257, 230-241.
  • Urstadt, K.R., Kally, P., Zaidi, S.F. and Stanley, B.G. (2013) Ipsilateral feeding-specific circuits between the nucleus accumbens shell and the lateral hypothalamus: Regulation by glutamate and GABA receptor subtypes. Neuropharmacology, 67, 176-182.
  • Stanley, B.G., Urstadt, K.R., Charles, J.R., and Kee, T. (2011) Glutamate and GABA in lateral hypothalamic mechanisms controlling food intake. Physiology and Behavior, 104, 40-46.
  • Hettes, S.R., Gonzaga, J.W., Heyming, T.W., Nguyen, J.K., Perez, S., Stanley, B.G. (2010) Stimulation of lateral hypothalamic AMPA receptors may induce feeding in rats. Brain Research, 1346, 112-120.
  • Turenius, C.I, Htut, M.H., Prodon, D.A., Ebersole, P.L., Ngo, P.T., Lara, R.N., Wilczynski, J.L. and  Stanley, B.G. (2009) GABAA receptors in the lateral hypothalamus as mediators of satiety and body weight regulation. Brain Research, 1262, 16-24.
  • Turenius, C.I., Charles, J.R., Tsai, D.H., Ebersole, P.L., Htut, M.H., Ngo, P.T. and Stanley, B.G. (2009)  The tuberal lateral hypothalamus is a major target for GABAA but not GABAB-mediated control of food intake. Brain Research, 1283, 65-72.
  • Khan, A.M., Ponzio, T.A., Sanchez-Watts, G., Stanley, B.G., Hatton, G.I., and Watts, A.G. (2007) Catecholaminergic control of mitogen-activated protein kinase signaling in paraventricular neuroendocrine neurons in vivo and in vitro: a proposed role during glycemic challenges. Journal of Neuroscience, 27(27), 7344-7360. 
  • Hettes, S.R., Heyming, T.W., and Stanley, B.G. (2007) Stimulation of lateral hypothalamic kainate receptors selectively elicits feeding behavior. Brain Research, 1184, 178-185.
  • Lee, S.W. & Stanley, B.G. (2005) NMDA receptors mediate feeding elicited by neuropeptide Y in the lateral and perifornical hypothalamus. Brain Research, 1063, 1-8.
  • Duva, M.A., Tomkins, E.M., Moranda, L.M., Kaplan, R., Sukhaseum, A., Stanley, B.G. (2005) Origins of lateral hypothalamic afferents associated with N-methyl-D-aspartic acid-elicited eating studied using reverse microdialysis of NMDA and Flurogold. Neuroscience Research, 52(1), 95-106.
  • Duva, M.A., Siu, A., and Stanley, B.G. (2005) Antagonist of NMDA receptors alters lipoprivic eating elicited by 2-mercaptoacetate. Physiology and Behavior, 83, 787-791.
  • Khan, A.M., Cheung, H.H., Gillard, E.R., Palarca, J.A., Welsbie, D.S., Gurd, J.W., and Stanley, B.G. (2004) Lateral hypothalamic signaling mechanisms underlying feeding stimulation: Differential contributions of Src family tyrosine kinases to feeding triggered either by NMDA injection or by food deprivation. Journal of Neuroscience, 24(47), 10603-10615.
  • Hettes, S.R., Gonzaga, J. Heyming, T.W., Perez, S., Wolfsohn, S. & Stanley, B.G. (2003) Dual roles in feeding for AMPA/kainate receptors: receptor activation or inactivation within distinct hypothalamic regions elicits feeding behavior, Brain Research, 992, 167-178.
  • Blevins J.E., Stanley B.G. and Reidelberger, R.D. (2002) DMSO as a vehicle for central injections: Tests with feeding elicited by norepinephrine injected into the paraventricular nucleus, Pharmacology Biochemistry and Behavior, 71(1-2), 277-282.
  • Duva, M.A., Tomkins, E.M., Moranda, L.M., Kaplan, R., Sukhaseum, A., Bernardo, J.P. and Stanley, B.G. (2002) Regional differences in feeding and other behaviors elicited by N-methyl-D-aspartic acid in the rodent hypothalamus: a reverse microdialysis mapping study, Brain Research, 925, 141-147.
  • Duva, M.A., Tomkins, E.M., Moranda, L.M., Kaplan, R., Sukhaseum, A., Jimenez, A. and Stanley, B.G. (2001) Reverse microdialysis of N-methyl-D-aspartic acid into the lateral hypothalamus of rats: effects on feeding and other behaviors, Brain Research, 921, 122-132.
  • Blevins, J.E., Stanley, B.G., & Reidelberger, R.D. (2000) Brain regions where cholecystokinin suppresses feeding in rats, Brain Research, 860, 1-10.
  • Blevins, J.E., Hamel, F.G., Fairbairn, E., Stanley, B.G., & Reidelberger, R.D. (2000) Effects of paraventricular nucleus injection on CCK-8 on plasma CCK-8 levels in rats, Brain Research, 860, 11-20.
  • Khan, A.M., Stanley, B.G., Bozzetti, L., Chin, C., Stivers, C. & Curras-Collazo, M.C. (2000) N-methyl-D-aspartate receptor subunit NR2B is widely expressed throughout the rat diencephalon: An immunohistochemical study, Journal of Comparative Neurology, 428, 428-449.
  • Khan, A.M., Curras, M.C., Dao, J., Jamal, F., Turkowski, C.A., Goel, R.K., Gillard, E.R., Wolfsohn, S.D. & Stanley, B.G. (1999) Lateral hypothalamic NMDA receptor subunits NR2A and/or NR2B mediate eating: immunochemical/behavioral evidence. American Journal of Physiology, 276, R880-R891.
  • Gillard, E.R., Khan, A.M., Mouradi, B., Nalamwar, O. & Stanley, B.G. (1998) Eating induced by perifornical hypothalamic cAMP is behaviorally selective and involves protein kinase activity. American Journal of Physiology, 275, R647-R653.
  • Marin Bivens, C.L., Thomas, W.J. & Stanley, B.G. (1998). Similar feeding patterns are induce by perifornical neuropeptide Y injection and food deprivation, Brain Research, 782, 271-280.
  • Gillard, E.R., Khan, A.M., Grewal, R.S., Mouradi, B., Wolfsohn, S.D. & Stanley, B.G. (1998) The second messenger cAMP elicits eating by an anatomically specific action in the perifornical hypothalamus, Journal of Neuroscience,18, 2646-2652.
  • Stanley, B.G., Butterfield, B.S., & Grewal, R.S. (1997). The NMDA receptor co-agonist glycine site: Evidence for a role in lateral hypothalamic stimulation of feeding. American Journal of Physiology, 273, R790-R796.
  • Gillard, E.R., Khan, A.M., Haq, A.U., Grewal, R.S., Mouradi, B., & Stanley, B.G. (1997). Stimulation of eating by the second messenger cAMP in the perifornical and lateral hypothalamus. American Journal of Physiology, 273, R107-R112.
  • Aramakis, V.B., Stanley, B.G. & Ashe, J.H. (1996) Neuropeptide Y receptor agonists: Multiple effects on spontaneous activity in the paraventricular hypothalamus. Peptides, 17, 1349-1357.
  • Stanley, B.G., Willett III, V.L., Donias, H.W., Dee II, M.G. & Duva, M.A. (1996) Lateral hypothalamic NMDA receptors and glutamate as physiological mediators of eating and weight control. American Journal of Physiology, 270, R443-R449.

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Molecular, Cell and Systems Biology
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